VISION, CENTRALRapid visual stimulation induces N-methyl-D-aspartate receptor-dependent sensory long-term potentiation in the rat cortexClapp, Wesley C.a; Eckert, Michael J.b; Teyler, Tim J.c d; Abraham, Wickliffe C.b Author Information aResearch Center for Cognitive Neurosciences, University of Auckland, Auckland bDepartment of Psychology, University of Otago, Dunedin, New Zealand cMedical Education Program, University of Idaho, Moscow, Idaho and dDepartment of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington, USA Correspondence and requests for reprints to Mr Wesley Clapp, Psychology Department, City Campus, University of Auckland, Private Bag 92019, Auckland, New Zealand Tel: +64 9 373 7599 ext 84249; fax: +64 9 373 7450; e-mail: [email protected] Sponsorship: NIH grant R01 MH064508 and NZ Marsden Fund. Received 5 January 2006; revised 23 January 2006; accepted 24 January 2006 All procedures were approved by the University of Otago Ethics Committee. NeuroReport: April 3, 2006 - Volume 17 - Issue 5 - p 511-515 doi: 10.1097/01.wnr.0000209004.63352.10 Buy Metrics Abstract Previously we have demonstrated that rapidly presented sensory stimulation (visual or auditory) can induce long-lasting increases in sensory evoked potentials recorded from the human cortex. Long-term potentiation was suggested as the underlying mechanism of these increases. In the present experiment, we applied the same visual paradigm to anesthetized rats to investigate the properties and mechanisms of this effect. Our results indicated that visual evoked responses were significantly enhanced for at least 1 h and, when followed, up to 5 h after the presentation of a ‘photic tetanus.’ Furthermore, the potentiation was N-methyl-D-aspartate receptor-dependent and cortically generated. This type of sensory long-term potentiation may underlie perceptual learning, and serves as a model system for investigating sensory-evoked plasticity. © 2006 Lippincott Williams & Wilkins, Inc.