SOMATOSENSORY SYSTEMS, PAINDissociable modulating effect of repetitive transcranial magnetic stimulation on sensory and pain perceptionYoo, Woo-Kyounga; Kim, Yun-Heeb; Doh, Won-Suc; Lee, Ji-Huna; Jung, Kwang-Ika; Park, Dong-Sikd; Park, Eun-SookcAuthor Information aDepartment of Physical Medicine and Rehabilitation Medicine, Hallym University Sacred Heart Hospital, Dongan-ku, Anyang, Republic of Korea bDepartment of Physical Medicine and Rehabilitation, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-ku, Seoul, Republic of Korea cDepartment of Physical Medicine and Rehabilitation Medicine, Yonsei University College of Medicine, Seodaemun-ku, Seoul, Republic of Korea and dDepartment of Physical Medicine and Rehabilitation Medicine, Kangdong Sacred Heart Hospital, Gangdong-ku, Seoul, Republic of Korea Correspondence and requests for reprints to Dr Yun-Hee Kim, MD, PhD, Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea Tel: +82 2 3410 2824, 2818; fax: +82 2 3410 0388; e-mail: [email protected] Sponsorship: This research was supported by the Brain Research Center of the 21st Century Frontier Research Program, which was funded by the Ministry of Science and Technology of the Republic of Korea (Grant No. M103-KV010014 03-K2201 01430). Received 31 October 2005; revised 27 November 2005; accepted 28 November 2005 NeuroReport: February 6, 2006 - Volume 17 - Issue 2 - p 141-144 Buy Abstract The effects of high frequency repetitive transcranial magnetic stimulation on sensory perception and the pain tolerance thresholds were investigated applying both motor cortex stimulation and medial frontal cortex stimulation in normal study participants. Both the sensory perception and pain tolerance thresholds were significantly increased in the motor cortex stimulation, whereas the pain tolerance thresholds, but not the sensory perception was significantly decreased in the medial frontal cortex stimulation. These results suggest the dissociable modulating effects of sensory and pain perception by the high frequency repetitive transcranial magnetic stimulation on the medial pain regulating system, but not the lateral pain regulating system. © 2006 Lippincott Williams & Wilkins, Inc.