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A magnetoencephalography spatiotemporal analysis of neural activities during feature binding

Filbey, Francesca M.a; Holroyd, Tomb; Carver, Frederickb; Sunderland, Treya; Cohen, Robert M.a

doi: 10.1097/01.wnr.0000185020.75057.19

Previous literature shows that feature binding processes elicit fronto-hippocampal areas. The time course of this process, however, remains unknown. This is the first study that investigates feature binding using magnetoencephalography. Synthetic aperture magnetometry analysis was used to localize sources of increased power in the θ band during the encoding phases of a feature-binding task in the left and right medial frontal gyri (Brodmann's area 10) and left and right anterior cingulate gyri. Theta band synchronization was observed in many of these same areas, but also in other areas not noted to have increased θ band power suggesting a broad network of regions subserving the encoding phase of feature binding.

aGeriatric Psychiatry Branch, National Institute of Mental Health and

bNIMH MEG Core Facility, Bethesda, Maryland, USA

Correspondence and requests for reprints to Francesca M. Filbey, Department of Psychology, University of Colorado at Boulder, Muenzinger Building, D326-B, 345 UCB, Boulder, CO 80309-0345, USA

Tel: +1 302 492 9203; fax: +1 303 492 2967; e-mail:

Received 10 August 2005; revised 29 August 2005; accepted 30 August 2005

© 2005 Lippincott Williams & Wilkins, Inc.