AGEINGAge-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memoryPapassotiropoulos, Andreas1 CA; Henke, Katharina1; Aerni, Amanda1; Coluccia, Daniel1; Garcia, Esmeralda1; Wollmer, Marc A.1; Huynh, Kim-Dung1; Monsch, Andreas U.2; Stähelin, Hannes B.2; Hock, Christoph1; Nitsch, Roger M.1; de Quervain, Dominique J.-F.1Author Information 1Division of Psychiatry Research, University of Zurich, Lenggstr. 31, 8029 Zurich, Switzerland 2Memory Clinic, Geriatric University Hospital, 4031 Basel, Switzerland CACorresponding Author: email@example.com Received 24 March 2005; accepted 6 April 2005 NeuroReport: May 31st, 2005 - Volume 16 - Issue 8 - p 839-842 Buy SDC Abstract A polymorphism (His452Tyr) of the 5-hydroxytryptamine (5-HT)2a receptor is associated with episodic memory in healthy young humans. Because 5-HT2a-receptor density decreases with increasing age, we tested whether the 5-HT2a receptor genotype effect on memory is influenced by age. We investigated the association of the His452Tyr genotype with memory performance in 622 healthy study participants aged from 18 to 90 years. In young to middle-aged participants, age significantly influenced genotype effects on episodic memory: the His452Tyr genotype exerted a significant influence on memory only in young participants. In the group of elderly cognitively healthy participants, the His452Tyr genotype did not affect memory performance. We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory. © 2005 Lippincott Williams & Wilkins, Inc.