AGEINGAge-related effects of bromocriptine on sensory gating in rhesus monkeysLiu, Ning1 3 4; Yu, Shan2; Zhou, Yifeng2; Cai, Jingxia1 3; Ma, Yuanye1 3 CA Author Information 1Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 2School of Life Sciences, University of Science & Technology of China, Hefei 230027, PR China 3Center of Brain and Mind, Chinese Academy of Sciences, Beijing 100080, PR China 4The Graduate School of the Chinese Academy of Science, Beijing 100039, PR China CACorresponding Author and Address: [email protected] Received 29 January 2005; accepted 18 February 2005 NeuroReport: April 25, 2005 - Volume 16 - Issue 6 - p 603-606 Buy Abstract Declines in dopamine neurotransmission are a robust characteristic of the process of normal aging. Using neuroimaging, biochemical and cognitive methods, age-related reduction of D2 receptor has been noted in a wide range of species. On the other hand, it is well known that dopamine plays a crucial role in the modulation of sensory gating. Here, we examined age-related alterations of D2 receptor in rhesus monkeys, using a sensory gating paradigm. The direct D2 receptor agonist, bromocriptine, was characterized in young adult and aged monkeys. We found bromocriptine disrupted sensory gating in young adult monkeys but not in aged ones. Our results provided new evidence that there is a functional decline of D2 receptor in aged monkeys. © 2005 Lippincott Williams & Wilkins, Inc.