BRAIN IMAGINGFunctional disconnection of the semantic networks in schizophreniaKim, Jae-Jin1 2 3; Ho Seok, Jeong1 2; Park, Hae-Jeong3; Soo Lee, Dong4 5; Chul Lee, Myung4 5; Soo Kwon, Jun5 6 CAAuthor Information 1Department of Psychiatry 2Mind Mapping Laboratory, Institute of Behavioral Science in Medicine 3Department of Diagnostic Radiology, Yonsei University College of Medicine, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, Korea 4Department of Nuclear Medicine 5BK21 Human Life Sciences, Seoul National University 6Department of Psychiatry, Seoul National University College of Medicine & Neuroscience Institute, SNU-MRC, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea CACorresponding Author and Address: [email protected] Received 26 December 2004; accepted 18 January 2005 NeuroReport: March 15, 2005 - Volume 16 - Issue 4 - p 355-359 Buy Abstract Patients with schizophrenia exhibit deficits in semantic processing, which can form the basis of thought disorders. The objective of this study was to explore functional connectivity between the activated areas during semantic processing in schizophrenia. Twelve patients with schizophrenia and 12 healthy controls were studied with [15O]H2O positron-emission tomography during semantic judgment. The expected activation in the left inferior occipitotemporal cortex significantly correlated with several other regional activations in normal study participants, but with no other regional activations in patients with schizophrenia. This finding suggests that schizophrenia involves a disconnection of semantic networks. The resultant distortion in semantic processing may have an impact on thought disorders. © 2005 Lippincott Williams & Wilkins, Inc.