NEUROENDOCRINOLOGYGalanin-like peptide stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in ratsOnaka, Tatsushi1 CA; Kuramochi, Motoki1; Saito, Jun2; Ueta, Yoichi2; Yada, Toshihiko1Author Information 1Department of Physiology, Jichi Medical School, Minamikawachi-machi, Tochigi-ken 329-0498, Japan 2Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan CACorresponding Author: [email protected] Received 23 November 2004; accepted 29 December 2004 NeuroReport: February 28th, 2005 - Volume 16 - Issue 3 - p 243-247 Buy Abstract Galanin-like peptide is a recently identified neuropeptide. We examined the effects of stressful stimuli on expression of c-Fos protein in galanin-like peptide neurons, and the effects of central infusion of galanin-like peptide on release of stress hormones, vasopressin, oxytocin and adrenocorticotropic hormone, in male rats. Foot shock stress induced expression of c-Fos protein in galanin-like peptide neurons in the hypothalamus. Intracerebroventricular injection of galanin-like peptide significantly increased plasma concentrations of vasopressin, oxytocin and adrenocorticotropic hormone. Galanin-like peptide also increased blood pressure, heart rates and plasma glucose concentrations, but significantly changed neither plasma osmolality nor blood haemoglobin concentration. A neuropeptide Y-Y1 receptor antagonist, BIBP3226, did not significantly change galanin-like peptide-induced hormone release. It is possible that galanin-like peptide is involved in vasopressin, oxytocin and adrenocorticotropic hormone release from the pituitary during stress. © 2005 Lippincott Williams & Wilkins, Inc.