REGENERATION AND TRANSPLANTATIONNeuronal activity-induced regulation of Lingo-1Trifunovski, AlexandraCA; Josephson, Anna; Ringman, Andreas; Brené, Stefan; Spenger, Christian; Olson, LarsAuthor Information Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden CACorresponding Author: Alexandra.Trifunovski@neuro.ki.se Received 9 August 2004; accepted 3 September 2004 NeuroReport: October 25th, 2004 - Volume 15 - Issue 15 - p 2397-2400 Buy SDC Abstract Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that consists of Nogo receptor (NgR), p75NTR, and Lingo-1. Nogo binding activates RhoA, which inhibits axonal outgrowth. Here we assessed Lingo-1 and NgR mRNA levels after delivery of BDNF into the rat hippocampal formation, Lingo-1 mRNA levels in rats subjected to kainic acid (KA) and running in running wheels. Lingo-1 mRNA was not changed by running. However, we found that Lingo-1 mRNA was strongly up-regulated while NgR mRNA was down-regulated in the dentate gyrus in both the BDNF and the KA experiments. Our data demonstrate inverse regulation of NgR and Lingo-1 in these situations, suggesting that Lingo-1 up-regulation is one characteristic of activity-induced neural plasticity responses. © 2004 Lippincott Williams & Wilkins, Inc.