BRAIN IMAGINGDisgust and the insula: fMRI responses to pictures of mutilation and contaminationWright, P.1 2; He, G.2; Shapira, N. A.2; Goodman, W. K.2; Liu, Y.1 2 CAAuthor Information 1Departments of Neuroscience 2Psychiatry, University of Florida, 100 Newell Drive, Gainesville, FL 32610-0256, USA CACorresponding Author: [email protected] Received 10 July 2004; accepted 12 August 2004 NeuroReport: October 25th, 2004 - Volume 15 - Issue 15 - p 2347-2351 Buy Abstract Although previous functional brain imaging studies have found that the insula responds selectively to facial expressions of disgust, it remains unclear whether the insula responds selectively to disgust-inducing pictures. In this fMRI study, healthy volunteers viewed pictures of contamination, human mutilation, attacks and neutral scenes during scanning, and then rated pictures for the ‘basic’ emotions. The anterior insula responded to contamination and mutilation but not attacks, while the ventral visual areas responded to attacks and mutilations more strongly than contamination. The above activations were predicted by disgust and arousal ratings respectively. Additionally, mutilations uniquely activated the right superior parietal cortex. These results support selective disgust processing at the insula, and suggest distinct neural responses to contamination and mutilation. © 2004 Lippincott Williams & Wilkins, Inc.