SLEEPSleep EEG changes after zolpidem in miceKopp, Caroline1; Rudolph, Uwe; Tobler, IreneCAAuthor Information Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland 1Present address: Dept. of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland CACorresponding Author: email@example.com Received 12 July 2004; accepted 2 August 2004 NeuroReport: October 5th, 2004 - Volume 15 - Issue 14 - p 2299-2302 Buy SDC Abstract Zolpidem is a widely used hypnotic that binds preferentially to α1GABAA receptors. We determined the role of these receptors in the effects of zolpidem on sleep in mutant mice carrying zolpidem-insensitive α1GABAA receptors and wild-type controls. Sleep was promoted by zolpidem in both genotypes. In wild-type mice non-REM sleep EEG power was markedly reduced in a broad frequency band >5 or 9 Hz after 5 and 10 mg/kg zolpidem, respectively. In mutants a power reduction appeared at the highest dose only, and was restricted to some low frequencies and the 9–10 Hz bin. We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by α1GABAA receptors. © 2004 Lippincott Williams & Wilkins, Inc.