NEUROPHARMACOLOGY AND NEUROTOXICOLOGYInsulin growth factor-1 protects against excitotoxicity in the rat striatumEscartin, Carole; Boyer, Frédéric; Bemelmans, Alexis-Pierre1; Hantraye, Philippe; Brouillet, EmmanuelCAAuthor Information Unité de Recherche Associée 2210 Commissariat à l'Energie Atomique-Centre National de la Recherche Scientifique, and Program ImaGene, Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, Direction des Sciences du Vivant, 4 place du Général Leclerc, 91401 Cedex, Orsay, France 1Laboratoire d'oculogénétique, Hôpital Ophtalmique Jules Gonin, Avenue de France 15, 1004 Lausanne, Switzerland CACorresponding Author: Brouille@shfj.cea.fr Received 17 May 2004; accepted 20 July 2004 NeuroReport: October 5th, 2004 - Volume 15 - Issue 14 - p 2251-2254 Buy SDC Abstract Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntington's disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntington's disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 μg/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntington's disease. © 2004 Lippincott Williams & Wilkins, Inc.