VISION, CENTRALVisual responses to targets and distracters by inferior temporal neurons after lesions of extrastriate areas V4 and TEOBertini, Giuseppe1 3 CA; Buffalo, Elizabeth A.2; De Weerd, Peter1 4; Desimone, Robert2; Ungerleider, Leslie G.1Author Information 1Laboratory of Brain and Cognition, NIMH, 10 Center Drive 2Laboratory of Neuropsychology, NIMH, 49 Convent Drive, Bethesda, MD 20892, USA 3Present address: Department of Morphological and Biomedical Sciences, University of Verona, Strada le Grazie 8, 37134 Verona, Italy 4Present Address: Psychology Department, Neurocognition Group, University of Maastricht, The Netherlands CACorresponding author: [email protected] Received 7 April 2004; accepted 20 May 2004 NeuroReport: July 19, 2004 - Volume 15 - Issue 10 - p 1611-1615 doi: 10.1097/01.wnr.0000134847.86625.15 Buy Metrics Abstract While lesions of visual areas V4 and TEO only modestly affect discrimination of isolated objects, they significantly impair the ability to selectively attend to an object surrounded by distracters. To test whether such deficits result from a loss of inputs to higher order areas, we recorded from area TE neurons after removing portions of V4 and TEO in a monkey. Responses to isolated targets in a lesion-affected visual quadrant were substantially preserved, indicating that TE still receives information even after removing a major source of input. Distracters increased or decreased the response to targets more in the lesion-affected than in the normal quadrant, supporting the idea that V4 and/or TEO are sites where top-down attentional inputs filter out distracting stimuli. © 2004 Lippincott Williams & Wilkins, Inc.