NEUROCHEMISTRYEnhancement of NMDA responses by β-amyloid peptides in the hippocampus in vivoMolnár, Zsolt1 2; Soós, Katalin1; Lengyel, Imre3; Penke, Botond1 4; Szegedi, Viktor1 2; Budai, Dénes2 CAAuthor Information 1Department of Medical Chemistry 2Department of Biology, Juhász Gyula College, University of Szeged, Boldogasszony sgt. 6, Szeged 6721 3Department of Biochemistry, Biological Research Center 4Protein Research Group of the Hungarian Academy of Sciences, Szeged, Hungary CACorresponding Author: email@example.com Received 27 February 2004; accepted 9 March 2004 NeuroReport: July 19th, 2004 - Volume 15 - Issue 10 - p 1649-1652 doi: 10.1097/01.wnr.0000134471.06244.d2 Buy SDC Metrics Abstract The effects of Alzheimer's disease-related beta-amyloid (Aβ) peptides on the N-methyl-D-aspartate (NMDA)-evoked cell firing rate were studied in hippocampal CA1 neurons of the rat. Extracellular single-unit recordings were combined with iontophoretic applications that allowed quantitative analyses of the interactions between Aβ peptides and NMDA receptor-mediated events in vivo. The NMDA responses were significantly increased both by the full length Aβ1-42 and by its model fragment Aβ25-35. Enhancements of the NMDA responses by the Aβ peptides lasted about 15 min and were irreversible. The effects of Aβ25-35 were prevented by the pentapeptide Lys-Leu-Val-Gly-Phe-amide (KLVGF) and were not evoked when its reversed sequence (Aβ35-25) was applied. © 2004 Lippincott Williams & Wilkins, Inc.