REGENERATION AND TRANSPLANTATIONCNS grafts of rat choroid plexus protect against cerebral ischemia in adult ratsBorlongan, C. V.1 2 CA; Skinner, S. J. M.4; Geaney, M.4; Vasconcellos, A. V.3; Elliott, R. B.4; Emerich, D. F.3Author Information 1Department of Neurology/Institute of Molecular Medicine and Genetics/School of Graduate Studies, BI-3080, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-3200, USA 2Research and Affiliations Service Line, Augusta VAMC, Augusta, GA, USA 3LCTBioPharma, Inc., Providence, RI 4DiatraNZ/Living Cell Technologies, Auckland, New Zealand CACorresponding Author: email@example.com Received 7 March 2004; accepted 19 March 2004 NeuroReport: July 19th, 2004 - Volume 15 - Issue 10 - p 1543-1547 doi: 10.1097/01.wnr.0000133298.84901.cf Buy SDC Metrics Abstract The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependant protection of embryonic cortical neurons against serum deprivation-induced cell death. In vivo studies demonstrated that a one-hour middle cerebral artery occlusion in adult Wistar rats produced profound motor and neurological impairments 1–3 days after stroke. In contrast, stroke animals transplanted with encapsulated choroid plexus cells displayed a significant reduction in both motor and neurological abnormalities. Histological analysis 3 days post-transplantation revealed that choroid plexus transplants significantly decreased the volume of striatal infarction. This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke. © 2004 Lippincott Williams & Wilkins, Inc.