VISION, RETINAAngiogenesis-related factors derived from retinal glial (Müller) cells in hypoxiaEichler, Wolfram1 CA; Yafai, Yousef1 2; Wiedemann, Peter1; Reichenbach, Andreas2Author Information University of Leipzig, 1Eye Hospital, Liebigstrasse 10-14, D-04103 Leipzig, Germany 2Paul Flechsig Institute for Brain Research, Department of Neurophysiology, Jahnallee 59, D-04109 Leipzig, Germany CACorresponding Author: firstname.lastname@example.org Received 27 February 2004; accepted 11 May 2004 NeuroReport: July 19th, 2004 - Volume 15 - Issue 10 - p 1633-1637 doi: 10.1097/01.wnr.0000133071.00786.a4 Buy Metrics Abstract Retinal glial (Müller) cells may play a major role in vascular eye diseases as they secrete vascular endothelial growth factor (VEGF), a hypoxia-induced angiogenic cytokine. They also release significant amounts of the anti-angiogenic factors, transforming growth factor (TGF)-β2, pigment epithelium derived factor (PEDF), and thrombospondin-1 (TSP-1). Exposure of human (MIO-M1) and guinea-pig Müller cells to hypoxia resulted in a decreased release of TGF-β2 and PEDF but in an elevated secretion of TSP-1. When retinal endothelial cells were exposed to VEGF/anti-angiogenic factor ratios mimicking those found in culture media of Müller cells under normoxia or hypoxia, their proliferation was significantly inhibited by TGF-β2, PEDF or TSP-1. Thus Müller cells may provide a permanent anti-proliferative condition for retinal endothelial cells. © 2004 Lippincott Williams & Wilkins, Inc.