COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYA dissociation between real and simulated movements in Parkinson's diseaseFrak, VictorCA; Cohen, Henri; Pourcher, Emmanuelle1 Author Information Cognitive Neuroscience Center, Université du Québec à Montréal, PB. 8888, Stn. Centre-Ville, Montreal, Qc. H3C 3P8 1Movement and Memory Disorder Clinic, Polyclinique Ste-Anne, Québec, Canada CACorresponding Author: [email protected] Received 29 March 2004; accepted 27 April 2004 NeuroReport 15(9):p 1489-1492, June 28, 2004. | DOI: 10.1097/01.wnr.0000132429.68206.48 Buy Metrics Abstract Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson's disease motor imagery is impaired and that execution of overt movements is spared. This constitutes the first lesion observation congruent with the anatomical and functional dichotomy between real and simulated movements seen in experimental studies. These results underline the modality-specific nature of motor imagery and show that subcortical damage differentially impacts on motor activity. © 2004 Lippincott Williams & Wilkins, Inc.