SOMATOSENSORY SYSTEMS, PAINModulation of thermal pain-related brain activity with virtual reality: evidence from fMRIHoffman, Hunter G.CA; Richards, Todd L.1; Coda, Barbara2; Bills, Aric R.4; Blough, David3; Richards, Anne L.1; Sharar, Sam R.4Author Information Human Interface Technology Lab, and Department of Radiology, Box 352142 1Department of Radiology, Box 357115 3Department of Pharmacy, Box 357630, University of Washington, 1959 NE Pacific, Seattle, WA 98195 4Department of Anesthesiology, Box 359724 2Department of Anesthesiology, Box 356540, University of Washington, Seattle, WA 98104, USA CACorresponding Author: hunter@hitL.washington.edu Received 27 January 2004; accepted 17 March 2004 NeuroReport: June 7th, 2004 - Volume 15 - Issue 8 - p 1245-1248 doi: 10.1097/01.wnr.0000127826.73576.91 Buy SDC Metrics Abstract This study investigated the neural correlates of virtual reality analgesia. Virtual reality significantly reduced subjective pain ratings (i.e. analgesia). Using fMRI, pain-related brain activity was measured for each participant during conditions of no virtual reality and during virtual reality (order randomized). As predicted, virtual reality significantly reduced pain-related brain activity in all five regions of interest; the anterior cingulate cortex, primary and secondary somatosensory cortex, insula, and thalamus (p<0.002, corrected). Results showed direct modulation of human brain pain responses by virtual reality distraction. © 2004 Lippincott Williams & Wilkins, Inc.