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Increased anxiety in mice lacking vitamin D receptor gene

Kalueff, Allan V.1 CA; Lou, Yan-Ru1; Laaksi, Ilkka2; Tuohimaa, Pentti1 3

doi: 10.1097/01.wnr.0000129370.04248.92

Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various behavioural disorders. To examine this problem, we studied whether genetic ablation of vitamin D receptors in mice may be associated with altered emotional behaviours. Here we show that the receptor-deficient mice demonstrate increased anxiety-like behaviours when subjected to a battery of behavioural tests. These studies suggest that vitamin D and its receptors are an important factor in the brain, whose imbalance may significantly affect emotional behaviour.

1Department of Anatomy

2Department of Cell Biology, Medical School, University of Tampere

3Department of Clinical Chemistry, University of Tampere Hospital, FIN-33014 Tampere, Finland

CACorresponding Author:

Received 17 February 2004; accepted 31 March 2004

© 2004 Lippincott Williams & Wilkins, Inc.