BRAIN IMAGINGPseudo-neglect in Huntington's disease correlates with decreased angular gyrus densityHo, Aileen K.1 2 CA; Nestor, Peter J.3; Williams, Guy B.4; Bradshaw, John L.5; Sahakian, Barbara J.6; Robbins, Trevor W.7; Barker, Roger A.1 3Author Information 1Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK 2School of Psychological Science, La Trobe University, Victoria 3086, Australia 3Department of Neurology, Addenbrooke's Hospital, Cambridge, UK 4Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, UK 5Department of Psychology, Monash University, Melbourne, Australia 6Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK 7Department of Experimental Psychology, University of Cambridge, Cambridge, UK CA,1Corresponding author and Address: [email protected] Received 29 January 2004; accepted 6 February 2004 NeuroReport: April 29, 2004 - Volume 15 - Issue 6 - p 1061-1064 Buy Abstract Visuospatial attentional bias was examined in Huntington's disease (HD) patients with mild disease, asymptomatic gene-positive patients and controls. No group differences were found on the grey scales task (which is a non-motor task of visuospatial attentional bias), although patients' trinucleotide (CAG) repeat length correlated with increasing leftward bias. On the line bisection task, symptomatic patients made significantly larger leftward bisection errors relative to controls, who showed the normal slight degree of leftward error (pseudo-neglect). The asymptomatic group showed a trend for greater leftward error than controls. A subset of participants went on to have structural MRI, which showed a correlation between increased leftward error on the line bisection task and reduced density in the angular gyrus area (BA39) bilaterally. This finding is consistent with recent literature suggesting a critical role for the angular gyrus in the lateralization of visuospatial attention. © 2004 Lippincott Williams & Wilkins, Inc.