COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYProton magnetic resonance spectroscopy in anorexia nervosa: correlations with cognitionOhrmann, PatriciaCA; Kersting, Anette; Suslow, Thomas; Lalee-Mentzel, Judith; Donges, Uta-Susan; Fiebich, Martin2; Arolt, Volker; Heindel, Walter1; Pfleiderer, Bettina1Author Information University of Münster, Department of Psychiatry, Albert-Schweitzer-Str. 11 1Department of Clinical Radiology, Albert-Schweitzer-Str. 33, 48129 Münster 2University of Applied Sciences, Department of Biomedical Engineering, Wiesenstr. 14, 35390 Giessen, Germany CACorresponding Author: firstname.lastname@example.org Received 17 October 2003; accepted 3 November 2003 NeuroReport: March 1st, 2004 - Volume 15 - Issue 3 - p 549-553 Buy SDC Abstract The aim of this study was to investigate the relationship between cognitive impairment and cerebral metabolites in patients with anorexia nervosa (AN). N-acetylaspartate (NAA), creatine/phosphocreatine (Cr), choline-containing compounds, glutamate/glutamine (Glx) and myoinositol were measured by proton magnetic resonance spectroscopy (1H-MRS) of the left prefrontal cortex. Compared with healthy controls, AN patients displayed a significantly poorer performance in verbal learning and in attentional and executive tasks. Performance in the divided attention task was correlated with NAA and Cr in the dorsolateral prefrontal cortex, while executive functioning and depressive symptomatology were associated with Glx levels in the anterior cingulate. Our results provide evidence for cognitive impairment in AN patients which is associated with cerebral metabolism in the prefrontal cortex. © 2004 Lippincott Williams & Wilkins, Inc.