MOTOR SYSTEMSCortical activation changes associated with motor recovery in patients with precentral knob infarctJang, Sung HoCA; Cho, Sang-Hyun1; Kim, Yun-Hee2; Kwon, Yong-Hyun3; Byun, Woo Mok4; Lee, Se Jin5; Park, Sung Min3; Chang, Chul Hoon6 Author Information Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Taegu, 705-717 1Department of Physical Therapy, Yonsei University College of Health Science, Wonju-si, Kangwon-do, 220-710 2Department of Physical Medicine and Rehabilitation, School of Medicine Sungkyunkwan University, Samsung Medical Center, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710 3Departments of Physical Medicine and Rehabilitation 4Diagnostic Radiology 5Neurology 6Neurosurgery, School of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Taegu 705-717, Republic of Korea CACorresponding Author: [email protected] Received 22 November 2003; accepted 11 December 2003 NeuroReport: March 1, 2004 - Volume 15 - Issue 3 - p 395-399 Buy Abstract We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for the primary sensorimotor cortex (SM1) was calculated to measure the degree of the cortical activity concentration in the contralateral hemisphere. Our results showed that a greater improvement in motor function scores was significantly correlated with a greater increment in LI induced by affected finger movements (p < 0.05). Motor recovery after precentral knob infarct was found to be positively related with the concentration of SM1 activity in the ipsilesional hemisphere. This finding may imply motor recovery through cortical reorganization after precentral knob infarct in the human brain. © 2004 Lippincott Williams & Wilkins, Inc.