CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYAnalysis of hippocampal atrophy in alcoholic patients by a Kohonen feature mapKurth, ChristophCA; Wegerer, Viola1; Reulbach, Udo2; Lewczuk, Piotr2; Kornhuber, Johannes2; Steinhoff, Bernhard J.; Bleich, Stefan2 Author Information Epilepsy Centre Kehl-Kork, 77694 Kehl-Kork, Germany 1Department of Psychiatry and Psychotherapy, University of Göttingen, 37075 Göttingen 2Department of Psychiatry and Psychotherapy, University of Erlangen, 91054 Erlangen, Germany CACorresponding Author: [email protected] Received 29 September 2003; accepted 16 October 2003 NeuroReport 15(2):p 367-371, February 9, 2004. Buy Abstract We investigated the correlation of hippocampal volume with homocysteine, folate, vitamin B12 and B6 in alcoholic patients and healthy controls applying a Kohonen feature map (KFM) and conventional statistics. Representation of subjects on the KFM suggested an inverse correlation of hippocampal volume with blood levels of homocysteine and correlation with folate and vitamin B6. In conventional statistical analyses (t-test) reduced folate and increased homocysteine was found in alcoholics compared to healthy controls (p < 0.01). In female alcoholics vitamin B6 was reduced significantly (p = 0.03). Multiple linear regression analyses showed a significant correlation between average hippocampal volume and homocysteine (p < 0.001). KFM proved to be a sensitive tool for visualisation of statistical correlations in data sets even if no further statistical information is available. © 2004 Lippincott Williams & Wilkins, Inc.