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Transplantation of bone marrow stromal cells into the cochlea of chinchillas

Naito, YasushiCA; Nakamura, Tatsuo1; Nakagawa, Takayuki; Iguchi, Fukuichiro; Endo, Tsuyoshi; Fujino, Kiyohiro; Kim, Tae-Soo; Hiratsuka, Yasuyuki; Tamura, Tetsuya; Kanemaru, Shin-ichi; Shimizu, Yoshihiko1; Ito, Juichi


This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with DiI were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multiple regions within the cochlea. Marrow cells implanted in the basal turn of the cochlea migrated as far as the apical end or into the spiral ligament of the cochlea. Some grafted cells expressed a neuronal or glial cell marker, indicating their ability to differentiate into neuronal or glial cells. Survival, migrational mobility and differentiation of autologous marrow cells in damaged cochlea suggest their potential as transplants for treatment of various degenerative inner ear diseases.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine and

1Institute for Frontier Medical Science, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan

CACorresponding Author:

Received 2 July 2003; accepted 7 August 2003

© 2004 Lippincott Williams & Wilkins, Inc.