BRAIN IMAGINGSex differences in frontal lobe white matter microstructure: a DTI studySzeszko, Philip R.1 2 CA; Vogel, Joshua1; Ashtari, Manzar3; Malhotra, Anil K.1 2; Bates, John1; Kane, John M.1 2; Bilder, Robert M.4; Frevert, Theresa1; Lim, Kelvin5 Author Information 1Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore–Long Island Jewish Health System, Glen Oaks, 75–59 263rd Street, Glen Oaks, NY 11004 2Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 3Department of Radiology, North Shore–Long island Jewish Health System, New Hyde Park, NY 4UCLA Neuropsychiatric Institute and Hospital, Geffen School of Medicine at UCLA, Los Angeles, CA 5Department of Psychiatry and Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA CACorresponding Author: [email protected] Received 4 August 2003; accepted 10 September 2003 NeuroReport: December 19, 2003 - Volume 14 - Issue 18 - p 2469-2473 Buy Abstract There is evidence that the brains of men and women are structurally different, but there are few data regarding possible sex differences in white matter microstructure. Using diffusion tensor imaging we assessed fractional anisotropy (FA) in the frontal lobe white matter on contiguous 5 mm slices in nine healthy male and 11 healthy female adults. Overall, women had higher FA in the left frontal lobe compared to men and a leftward asymmetry of FA in contrast to men, who showed no hemispheric asymmetry. Among women, greater leftward asymmetry of frontal lobe FA correlated significantly with better verbal comprehension and memory functioning. Our findings may be indicative of increased directional coherence and/or density of left hemisphere white matter fibers and a leftward asymmetry of this structural integrity among women compared to men. © 2003 Lippincott Williams & Wilkins, Inc.