ArticlespH modulates the vestibular afferent discharge and its response to excitatory amino acidsVega, Rosario1,CA; Mercado, Francisco1; Chávez, Hortencia1,2; Limón, Agenor1; Almanza, Angélica1,2; Ortega, Aída1; Pérez, Ma. Eugenia3; Soto, Enrique1Author Information 1Instituto de Fisiología, BUAP; 2Facultad de Estomatología; 3Escuela de Biología, Universidad Autónoma de Puebla, Apartado Postal 406, Puebla, Pue. 72000, México CACorresponding Author: [email protected] Received 14 January 2003; accepted 19 February 2003 NeuroReport: July 18, 2003 - Volume 14 - Issue 10 - p 1327-1328 doi: 10.1097/01.wnr.0000078382.40088.0b Buy Metrics Abstract In the isolated inner ear of the axolotl (Ambystoma tigrinum) acid pH decreased and basic pH increased the resting and mechanically evoked spike discharge of semicircular canal afferent neurons. Variations in pH also modified the afferent neuron response to N-methyl-D-aspartic acid (NMDA) acid and to (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). Responses to both excitatory amino acid agonists increased at pH 7.8 (41% and 22%, respectively) and decreased by perfusion of the preparation with a saline solution, of pH 7.0 (28% in both cases). These results indicate that vestibular endorgans have a significant sensitivity to pH that could play a significant role in various pathological states, and may also contribute to the post-transductional processing of sensory information. © 2003 Lippincott Williams & Wilkins, Inc.