ArticlesAltered processing of novel information in N-CAM-deficient miceMontag-Sallaz, M.1,2,CA; Montag, D.1,2; Schachner, M.1,3 Author Information 1Department of Neurobiology, Swiss Federal Institute of Technology (ETH), Hoenggerberg,CH-8093 Zurich, Switzerland; 2Neurogenetics Research Group, Leibniz Institute for Neurobiology, Brenneckestr. 6, D-39118 Magdeburg; 3Zentrumfür Molekulare Neurobiologie, Universität Hamburg, Martinistr. 52, D-20246 Hamburg, Germany CA,2Corresponding Author and Address: [email protected] NeuroReport: July 18, 2003 - Volume 14 - Issue 10 - p 1343-1346 doi: 10.1097/01.wnr.0000077549.91466.4c Buy Metrics Abstract N-CAM-deficient mice display anatomical and electrophysiological abnormalities in the CNS and behavioral deficits. Here, we address the question whether information processing is altered in these mice by analysis of the expression of c-fos and arg 3.1/arc in NCAM- deficient mice after presentation of saccharin as novel or familiar and water as neutral gustatory stimulus. When compared to their wild-type control littermates, increased expression of c-fos mRNA in the amygdala after the novel taste and of arg 3.1/arc mRNA in the dentate gyrus 4.5 h after the neutral taste was detected in the absence of N-CAM. Furthermore, the novelty-induced increase in arg 3.1/arc expression in the cingulate cortex 4.5 h after the novel taste was not observed in N-CAM-deficient mice. These data suggest that information processing mediated by immediate-early gene expression is altered in N-CAM-deficient mice. NeuroReport 14:1343–1346 © 2003 Lippincott Williams & Wilkins. © 2003 Lippincott Williams & Wilkins, Inc.