BRAIN IMAGINGFunctional neuroimaging predicts individual memory outcome after amygdalohippocampectomyHenke, Katharina,1; Treyer, Valerie2; Weber, Bruno2,3; Nitsch, Roger M1; Hock, Christoph1; Wieser, Heinz Gregor3; Buck, Alfred2Author Information 1Division of Psychiatry Research, University of Zürich, Lenggstrasse 31, 8029 Zürich; 2PET Center, Division of Nuclear Medicine, University Hospital Zürich, Rämistrasse 100, 8091 Zürich, 3Department of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, SwitzerlandCACorresponding Author: [email protected] Received 20 March 2003; accepted 22 April 2003 NeuroReport: July 1, 2003 - Volume 14 - Issue 9 - p 1197-1202 Buy Abstract We examined memory-related activity within to-be-resected medial temporal lobe (MTL) structures in 12 epilepsy patients with PET before amygdalohippocampectomy and studied the reallocation of memory functions to the contralateral MTL before and after surgery. Learning tasks were designed to activate predominantly the right or left MTL. Those patients who significantly activated to-be-resected ipsilateral MTL structures during the ipsilateral learning task (i.e. the left MTL during verbal learning or the right MTL during nonverbal learning) experienced a postoperative memory decline. Preoperative activation in the contralateral MTL during the ipsilateral learning task positively correlated with the postoperative outcome for ipsilateral memory. There was no significant postoperative reallocation of ipsilateral memory functions to the contralateral MTL. © 2003 Lippincott Williams & Wilkins, Inc.