BRAIN IMAGINGSeparate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actorsPelletier, Mario; Bouthillier, Alain; Lévesque, Johanne1; Carrier, Serge2; Breault, Claude3; Paquette, Vincent3; Mensour, Boualem; Leroux, Jean-Maxime; Beaudoin, Gilles; Bourgouin, Pierre; Beauregard, Mario2 4 5 6 CAAuthor Information Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal (Québec) 1Département de psychologie and Groupe de Recherche en Neuropsychologie Expérimentale et Cognition 2Département de psychologie, Université Concordia, Montréal (Québec) 3Centre de recherche, Institut universitaire de gériatrie de Montréal), 4565 Queen Mary Rd, Montréal (Québec) Canada, H3W 1W5 4Centre de recherche en sciences neurologiques 5Department de radiologie, Université de Montréal, Montréal (Québec) CACorresponding Author and Address: firstname.lastname@example.org Received 10 February 2003; accepted 28 February 2003 NeuroReport: June 11th, 2003 - Volume 14 - Issue 8 - p 1111-1116 Buy Abstract The question of whether distinct or similar neural substrates underlie primary emotions has not been resolved yet. To address this issue, we used fMRI to scan professional actors during self-induced states of sadness and happiness. Results demonstrated that, relative to an emotionally Neutral state, both the Sad and the Happy states were associated with significant loci of activation, bilaterally, in the orbitofrontal cortex, and in the left medial prefrontal cortex, left ventrolateral prefrontal cortex, left anterior temporal pole, and right pons. These loci of activation were localized distinctly within these regions, that is, in different sub-regions. These results suggest that sadness and happiness may be associated with similar brain regions but distinct sub-regions and neural circuits. © 2003 Lippincott Williams & Wilkins, Inc.