NeuroReportKinetic variability of AMPA receptors among olfactory bulb neurons in cultureBlakemore, Laura J.CA; Trombley, Paul Q. Author Information Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306–4340, USA CACorresponding Author: [email protected] Received 15 January 2003; accepted 18 February 2003 NeuroReport: May 23, 2003 - Volume 14 - Issue 7 - p 965-970 doi: 10.1097/01.wnr.0000070826.57864.00 Buy Metrics Abstract AMPA receptors, which are composed of four subunits (GluRI-4), help mediate synaptic transmission at most excitatory synapses in the brain. Their subunit composition influences the kinetics of AMPA receptor deactivation and desensitization, thus, the efficacy of synaptic transmission. Immunohistochemical data suggest that AMPA receptor subunit expression in the olfactory bulb (OB) follows a distinct laminar and cellular distribution. However, little is known about the kinetic properties of AMPA receptors on OB neurons. In this study, we used kinetic analysis and pharmacologic methods to demonstrate that the rate and extent of desensitization of OB AMPA receptors vary within and between neuronal subtypes. Such variability suggests that a broad functional diversity of AMPA receptors contributes to olfactory information processing. NeuroReport 14:965–970 © 2003 Lippincott Williams & Wilkins. © 2003 Lippincott Williams & Wilkins, Inc.
