AUDITORY AND VESTIBULAR SYSTEMSNADPH-diaphorase-positive neurons in the auditory cortex of young and old ratsOuda, L.; Nwabueze-Ogbo, F. C.; Druga, R.1; Syka, J.CAAuthor Information Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 1Department of Functional Anatomy, 2nd Medical Faculty, Charles University, Prague, Czech Republic CACorresponding Author: firstname.lastname@example.org Received 18 October 2002; accepted 7 January 2003 NeuroReport: March 3rd, 2003 - Volume 14 - Issue 3 - p 363-366 Buy SDC Abstract Age-related changes in NADPH-diaphorase (NADPH-d)-positive neurons were examined in the auditory cortex of young (3 months old) and very old (36 months old) rats (strain Long Evans). In very old rats a significant reduction was found in the thickness of the auditory cortex, to 54% of that in young animals, as well as changes in the shape and configuration of nerve cell bodies and dendrites. Quantitative analysis demonstrated an age-related increase in the number of dendritic segments and dendritic branching points. The length of dendrites in NADPH-d-positive neurons and their density increased in very old rats. The total number of NADPH-d-positive neurons within the Te 1 and Te 3 fields was 13% lower in the old rats than in the young. © 2003 Lippincott Williams & Wilkins, Inc.