NEUROIMMUNOLOGYMyelin basic protein-reactive T cells induce conduction failure in vivo but not in vitroDevaux, Jérôme; Forni, Claude1; Beeton, Christine2; Barbaria, Jocelyne2; Béraud, Evelyne2; Gola, Maurice; Crest, MarcelCAAuthor Information Laboratoire Intégration des Informations Sensorielles, UMR 6150 1Laboratoire de Neurobiologie Cellulaire et Fonctionnelle, FRE 2131, CNRS, 31, Chemin Joseph-Aiguier, 13402 Marseille Cedex 20 2Laboratoire d'Immunologie, Faculté de Médecine, Université de la Méditerranée, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France CACorresponding Author: firstname.lastname@example.org Received 9 August 2002; accepted 9 December 2002 NeuroReport: March 3rd, 2003 - Volume 14 - Issue 3 - p 317-320 Buy Abstract The ability of myelin basic protein (MBP)-reactive T cells to induce conduction failure was investigated in vivo and in vitro. With the in vivo model, somatosensory evoked potentials (SEP) were recorded before and during adoptively transferred experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Maximum amplitude SEP were reached within 15 min of anesthesia. During EAE, the SEP decreased considerably and their onset was delayed. However, the compound action potentials (CAPs) recorded from Lewis rat optic nerves incubated with encephalitogenic T cells in vitro were not affected, emphasizing the importance of environmental factors. This study shows that the in vivo model described here is an useful means of investigating the neurological disorders associated with EAE. © 2003 Lippincott Williams & Wilkins, Inc.