DEVELOPMENTAL NEUROSCIENCEGalanin expression in sensory neurons after nerve compression or transectionDahlin, Lars B.CA; Stenberg, Lena; Kanje, Martin1Author Information Department of Hand Surgery, University Hospital Malmö, SE-205 02 Malmö 1Department of Cell and Organism Biology, Lund University, Lund, Sweden CACorresponding Author: email@example.com Received 18 October 2002; accepted 7 January 2003 NeuroReport: March 3rd, 2003 - Volume 14 - Issue 3 - p 359-362 Buy SDC Abstract Galanin is probably involved in nociceptive sensory processing in spinal cord. We investigated whether a common injury, peripheral nerve compression, induced up-regulation of galanin (immunocytochemistry) in sensory neurons in rats 6 or 14 days post-injury and compared the response with other nerve injuries. Sciatic nerve compression increased the number of galanin positive sensory neurons as compared to uninjured and contralateral dorsal root ganglia. Complete transection was more efficient than a partial transection and a slight compression injury as an inducer of galanin. Mainly small diameter sensory neurons became positive but also some large diameter neurons. We conclude that nerve compression up-regulates galanin in sensory neurons. The extent of the induction could be related to the severity of nerve injury. © 2003 Lippincott Williams & Wilkins, Inc.