CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYG protein β3 subunit 825T allele is associated with depression in young, healthy subjectsExton, Michael S.2 CA; Artz, Mike; Siffert, Winfried1; Schedlowski, ManfredAuthor Information Departments of Medical Psychology 1Pharmacology, University Clinic of Essen, Germany 2Present address: Eli Lilly Australia, 112 Wharf Rd, West Ryde, NSW 2114, Australia CA,2Corresponding Author and Address: firstname.lastname@example.org Received 24 July 2002; accepted 11 December 2002 NeuroReport: March 3rd, 2003 - Volume 14 - Issue 3 - p 531-533 Buy Abstract This study investigated the relationship between the G protein β3 subunit 825T allele and depression in young, heathy subjects. 825T and 825C allele carriers were characterized among 190 healthy medical students. State depression was assessed by the Becks Depression Inventory, supplemented by subscales of the Freiburg Personality Inventory, and Questionnaire for Measuring Factors of Aggression which assess trait depression. Depression of homo- and heterozygous 825T allele carriers was compared to 825C allele carriers via multi-level statistical analysis. 825T allele carriers displayed higher levels of depression, as measured by each questionnaire. Regression analysis demonstrated that allele type was the single predictor of depression. The predictive capacity of the 825T allele in depression was further supported by odds-ratio analysis. We conclude that the G protein β3 subunit 825T allele is predictive of depressive mood in a young, healthy population. © 2003 Lippincott Williams & Wilkins, Inc.