Antisaccade deficit after anterior cingulate cortex resectionMilea, D.CA; Lehéricy, S.1 5; Rivaud-Péchoux, S.4; Duffau, H.2; Lobel, E.; Capelle, L.2; Marsault, C.1; Berthoz, A.; Pierrot-Deseilligny, C.3 4NeuroReport: February 10th, 2003 - Volume 14 - Issue 2 - p 283-287 Motor Systems Buy SDC Abstract Author InformationAuthors Suppression of unwanted reflexive saccades is a crucial process allowing to sustain voluntary fixation, when required. This inhibition process, which is mainly controlled by the dorsolateral prefrontal cortex, may also involve other cortical and subcortical structures. We prospectively studied the effect of frontal cortical resections involving adjacent regions to the anterior cingulate cortex on the ability to inhibit reflexive saccades. This lesion study included six patients undergoing resection of frontal low grade gliomas, studied prior and after surgery with electro-oculography, using the antisaccade paradigm. Lesions were normalized and mapped in Talairach space allowing to detail the structures whose lesions were associated with antisaccade deficits. In three of the six patients significant early post-operative antisaccade errors were associated with resection of a common critical region, mainly involving the posterior part of the anterior cingulate cortex. This same region was spared in the three remaining patients with no antisaccade deficit, suggesting that the anterior cingulate cortex, known as the cingulate eye field, could play a role in suppression of unwanted saccades. Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, 13, place Marcelin Berthelot, 75005 Paris Departments of 1Neuroradiology 2Neurosurgery 3Neurology (Assistance Publique–Hôpitaux de Paris) 4INSERM U289 5EPI 007, Hôpital de la Pitié-Salpêtrière, Paris, France CACorresponding Author: email@example.com Received 18 October 2002; accepted 26 November 2002 © 2003 Lippincott Williams & Wilkins, Inc.