Clinical Neuroscience And NeuropathologyA new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhagePrunell, Giselle F.CA; Mathiesen, Tiit; Svendgaard, Niels-Aage Author Information Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Institutet, Box 130, 171 76, Stockholm, Sweden CACorresponding Author: [email protected] Received 31 January 2002; accepted 21 June 2002 NeuroReport: December 20, 2002 - Volume 13 - Issue 18 - p 2553-2556 Buy Abstract A new experimental model of subarachnoid hemorrhage (SAH) in rats is described. A needle was stereotaxically placed in the prechiasmatic cistern and 300, 250 or 200 μl of blood was injected manually, keeping the intracranial pressure (ICP) at the mean arterial blood pressure (MABP) level. An acceptable mortality was observed only after injection of 200 μl of blood. In this group, MABP and ICP increased immediately after SAH, but soon approached baseline levels. The subarachnoid blood was mainly distributed in the basal cisternal system and its estimated volume was about 95% of the amount injected. This new model resembles clinical SAH, is very reproducible, easy to use and seems to be a suitable model for studies of the pathophysiology of SAH. © 2002 Lippincott Williams & Wilkins, Inc.