Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Inhibition of voltage-gated Ca2+ channels by antazoline

Milhaud, Didier; Fagni, Laurent; Bockaert, Joël; Lafon-Cazal, MireilleCA

MEMBRANE AND CELLULAR BIOPHYSICS AND BIOCHEMISTRY
Buy
SDC

We showed recently that imidazolines exert neuroprotection against hypoxia and NMDA toxicity in cerebellar and striatal neuronal cultures, through a voltage-dependent blockade of glutamatergic NMDA receptors. Here, we report that in striatal neuronal cultures from mouse embryos the imidazoline compound, antazoline, inhibits voltage-gated Ca2+ channels by acting at a phencycli-dine-like site. This effect was fast, fully reversible, voltage-dependent and predominant on P/Q- and N-type Ca2+ channels. Taken together, these results suggest that imidazolines may elicit neuroprotective effects also by decreasing the release of glutamate through inhibition of presynaptic Ca2+ channels.

UPR CNRS 9023, CCIPE, 141, rue de la Cardonille, 34094 Montpellier Cedex 5, France

CACorresponding Author: lafon@montp.inserm.fr

Received 5 May 2002; accepted 10 July 2002

© 2002 Lippincott Williams & Wilkins, Inc.