SOMATOSENSORY SYSTEMS, PAINQuantitative analysis of nociceptin in blood of patients with acute and chronic painKo, Myoung-Hwan; Kim, Yun-Hee; Woo, Ran-Sook1; Kim, Kee-Won1 CAAuthor Information Department of Rehabilitation Medicine and Research Institute of Clinical Medicine 1Department of Pharmacology, Institute for Medical Sciences, Chonbuk National University Medical School, Keumam-dong, Chonju, Chonbuk 561-180, Republic of Korea CACorresponding Author Received 18 June 2002; accepted 10 July 2002 NeuroReport: September 16, 2002 - Volume 13 - Issue 13 - p 1631-1633 Buy Abstract This study aimed to define the change of serum level of nociceptin in pain patients. Seventy pain patients and 20 normal healthy subjects were enrolled. Patients were divided into three groups according to the duration of pain; (1) acute (within 4 weeks), (2) subacute (4 weeks to 6 months), and (3) chronic (> 6 months) state. Serum concentration of nociceptin was measured by radioimmunoassay. Serum nociceptin level was significantly higher in the patients with pain than in normal healthy subjects (p < 0.01). Furthermore, nociceptin level was significantly higher in the chronic pain group than acute group (p < 0.05). Serum nociceptin level has a relationship with the existence of pain and its duration. © 2002 Lippincott Williams & Wilkins, Inc.