Learning And MemoryRegional brain activations differ for semantic features but not categoriesLee, Andy C. H.1 CA; Graham, Kim S.1; Simons, Jon S.1; Hodges, John R.1 2; Owen, Adrian M.1 3; Patterson, Karalyn1 Author Information 1MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF 2University Neurology Unit, University of Cambridge, Box 165 3Wolfson Brain Imaging Centre, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK CACorresponding Author Received 7 May 2002 accepted 13 May 2002 Neuroreport 13(12):p 1497-1501, August 27, 2002. Buy Abstract Is human semantic knowledge neurally organised according to either category (e.g. living vs non-living) or attribute type (e.g. perceptual vs non-perceptual information)? Normal subjects were scanned using PET during a novel semantic production task, in which they generated either perceptual or non-perceptual information in response to names of living or non-living concepts. Analyses of blood flow in the temporal lobes revealed no significant differences associated with responses to living vs non-living concepts. Comparisons between retrieval of perceptual vs non-perceptual information, however, revealed significantly greater blood flow in left posterior inferior temporal cortex and right fusiform cortex associated with perceptual information and in left middle temporal cortex with non-perceptual information. These findings support a primarily attribute-based neural organisation of semantic knowledge. © 2002 Lippincott Williams & Wilkins, Inc.