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Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats

Parker, Linda A.CA; Mechoulam, Raphael1; Schlievert, Coralynne

Motivation, Emotion, Feeding, Drinking

Rats display conditioned rejection reactions during an oral infusion of a flavor previously paired with an emetic drug; considerable evidence indicates that these rejection reactions reflect nausea. Here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea.

Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada; 1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University Medical Faculty, Jerusalem 91120, Israel

CACorresponding Author

Received 18 January 2002 accepted 22 January 2002

© 2002 Wolters Kluwer Health | Lippincott Williams & Wilkins