Cognitive Neuroscience And NeuropsychologyLateral inhibition in the auditory cortex: An EEG index of tinnitus?Kadner, Alexander1 CA; Viirre, Erik1 2; Wester, Derin C.3; Walsh, Sally F.4; Hestenes, John1; Vankov, Andrey1; Pineda, Jaime A.1 5Author Information 1Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093-0515 2Department of Surgery, University of California, San Diego, La Jolla, CA 92093-0515 5Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093-0515 3Defense Spatial Orientation Center, Naval Medical Center San Diego 4Department of Communicative Disorders, San Diego State University, CA, USA CACorresponding Author Received 4 January 2002 accepted 11 January 2002 Neuroreport: March 25th, 2002 - Volume 13 - Issue 4 - p 443-446 Buy SDC Abstract Auditory ERPs were recorded from eight tinnitus patients and 12 controls. Tone pips of 1000 and 2000 Hz, as well as the patient's tinnitus pitch (around 4000 Hz) were used. Controls received tone pips at 1000, 2000, and 4000 Hz. Tones were presented at 30, 36, 42, 48 and 54 dB/SL. The intensity dependence of the auditory N100 was calculated for each frequency in each group. Patients showed a steeper response to the tinnitus frequency than responses to the 4000 Hz tone in controls. In contrast, intensity-dependence to the 2000 Hz tones was significantly decreased in patients (two-tailed Wilcoxon-Mann-Whitney U-test, p < 0.05). Responses to the 1000 Hz tones were similar for both groups. This reduced intensity dependence is hypothesized to result from lateral inhibition arising from tinnitus related activity in the 4000 Hz isofrequency region. © 2002 Lippincott Williams & Wilkins, Inc.