NEUROPHYSIOLOGY, BASIC AND CLINICALEarly thrombolysis inhibits peri-infarct depolarizations in embolic MCA occlusionSchüler, Olaf G.; Plesnila, Nikolaus1; Otto, Dörte2; Baethmann, Alexander J.1; Back, Tobias2, CAAuthor Information Department of Neurology and 1Institute of Surgical Research, Klinikum Grosshadern, Ludwig Maximilians-University, Marchioninistr. 15, D-81377 Munich; 2Department of Neurology, Philipps-University, Rudolf-Bultmann-Str. 8, D-35039 Marburg, Germany CACorresponding Author Received 3 October 2001; accepted 9 October 2001 Neuroreport: December 21st, 2001 - Volume 12 - Issue 18 - p 3943-3946 Buy SDC Abstract Rats submitted to middle cerebral artery (MCA) clot embolism were treated with tissue plasminogen activator (TPA) 1.5 and 3.5 h post-occlusion. Reperfusion patterns were monitored by measuring cortical laser-Doppler flow; the direct current potential was measured to detect peri-infarct depolarizations (PID), a known mechanism of ischemic injury. TPA treatment induced reperfusion in 58% of treated animals that was delayed by 41 ± 7 min (mean ± s.e.m.) from treatment onset. The prob- ability of reperfusion did not differ significantly between the two treatment groups. TPA treatment led to a 3-fold reduced frequency of PID if administered early or if successful reperfusion was observed (each p < 0.001). Early thrombolysis inhibits, but does not block, PID as an important mechanism of ischemic injury in embolic stroke. © 2001 Lippincott Williams & Wilkins, Inc.