Auditory And Vestibular SystemsThe role of acidic fibroblast growth factor in recovery of acoustic traumaSugahara, KazumaCA; Shimogori, Hiroaki; Yamashita, HiroshiAuthor Information Department of Otolaryngology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi, Japan CACorresponding Author Received 12 July 2001; accepted 10 August 2001 NeuroReport: October 29th, 2001 - Volume 12 - Issue 15 - p 3299-3302 Buy Abstract We administered acidic fibroblast growth factor (aFGF) to the perilymph of the guinea pig cochlea after exposure to intense sound to investigate its effect on the process of recovery after acoustic trauma. We assessed auditory brain stem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium using confocal laser-scanning microscopy. After noise exposure (120 dB SPL, 5 h), the ABR threshold showed an increase of ∼50 dB SPL that recovered after 14 days. Cochlear function in aFGF treated ears recovered more quickly than that in control ears. These results suggest that aFGF may play an important role in cochlear recovery after acoustic injury. © 2001 Lippincott Williams & Wilkins, Inc.