Molecular NeuroscienceThe POU domain transcription factor Brn-3a protects cortical neurons from apoptosisSmith, Martin D. Payne; Ensor, Elizabeth A.; Kinloch, Ross A.1; Latchman, David S.CAAuthor Information Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH; 1Neurologicals, Pfizer Central Research, Sandwich, UK CACorresponding Author Received 9 July 2001; accepted 7 August 2001 NeuroReport: October 29th, 2001 - Volume 12 - Issue 15 - p 3183-3188 Buy Abstract We have demonstrated previously that exogenously expressed Brn-3a is capable of protecting neurons of the peripheral nervous system against apoptosis. In these previous studies Brn-3a showed a degree of neuronal sub-type specificity, in that while it could promote survival in NGF-dependent sensory neurons, no effect was observed in NGF-dependent neurons of the sympathetic nervous system. In this report, we show that Brn-3a delivered using a herpes simplex virus is capable of protecting cultures of rat cerebrocortical neurons of the central nervous system against two types of cell death stimuli, including glutamate neurotoxicity. Hence the protective effect of Brn-3a is not confined to neurons of the peripheral nervous system but can also occur in neurons of the CNS. © 2001 Lippincott Williams & Wilkins, Inc.