Developmental NeuroscienceExpression of RA175 mRNA, a new member of the immunoglobulin superfamily, in developing mouse brainUrase, Koko; Soyama, Akiko; Fujita, Eriko; Momoi, TakashiCAAuthor Information Division of Development and Differentiation, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187-8502, Japan CACorresponding Author Received 9 July 2001; accepted 9 August 2001 NeuroReport: October 29th, 2001 - Volume 12 - Issue 15 - p 3217-3221 Buy Abstract RA175, a new member of the immunoglobulin superfamily, is highly expressed during neuronal differentiation of P19 embryonal carcinoma cells. In situ hybridization showed that RA175 mRNA was detected in the developing nervous system, as well as the epithelium of the various non-neuronal tissues of mouse embryo. In contrast with the epithelia of the non-neuronal tissues, RA175 mRNA was not co-expressed with Sonic hedgehog mRNA and Patched mRNA during brain morphogenesis. RA175 mRNA was highly expressed in the anterior horn cells and the peripheral nervous system at embryonic day (E) 11.5 and in the central nervous system at E14.5–E18.5, but its expression decreased after birth and was undetectable in the adult mouse brain. © 2001 Lippincott Williams & Wilkins, Inc.