Clinical Neuroscience And NeuropathologyBrain prolyl oligopeptidase activity is associated with neuronal damage rather than β-amyloid accumulationLaitinen, Kirsti S. M.CA; van Groen, Thomas1; Tanila, Heikki1; Venäläinen, Jarkko; Männistö, Pekka T.; Alafuzoff, Irina1,2Author Information Departments of Pharmacology and Toxicology and 1Neuroscience and Neurology, University of Kuopio, P.O.Box 1627, Fin-70211, Kuopio; 2Department of Pathology, Kuopio University Hospital, Kuopio, Finland CACorresponding Author Received 13 June 2001; accepted 8 August 2001 NeuroReport: October 29th, 2001 - Volume 12 - Issue 15 - p 3309-3312 Buy Abstract Prolyl oligopeptidase (POP) have been suggested to participate in the pathogenesis of Alzheimer's disease (AD). In this study the activity of POP is evaluated in AD patients and in transgenic mice with substantial deposits of β-amyloid (Aβ). In AD cases, the POP activity displayed a significant negative correlation with the scores of senile/neuritic plaques and neurofibrillary tangles but not with Aβ-load. The transgenic mice with high levels of Aβ did not have altered POP activity compared to wild type mice. Based on our results, the low POP activity in AD seems to be associated with neuronal degeneration rather than to Aβ accumulation. © 2001 Lippincott Williams & Wilkins, Inc.