Neurophysiology, Basic And ClinicalAge-dependent impairment of delay and trace eyeblink conditioning in miceKishimoto, Yasushi1,3; Suzuki, Michiyuki1; Kawahara, Shigenori1,2; Kirino, Yutaka1, CAAuthor Information 1Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033; 2CREST, JST, Saitama 332-0012, Japan.3Present address: Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan CACorresponding Author Received 30 May 2001; accepted 15 August 2001 NeuroReport: October 29th, 2001 - Volume 12 - Issue 15 - p 3349-3352 Buy Abstract The age effect on classical eyeblink conditioning in unrestrained mice (C57BL/6J strain) was evaluated. Mice were trained at one of three age periods (8, 45–50 or 85–90 weeks). In the delay paradigm, significant learning deficits were evident in the 85–90 week-old group, but no deficits were observed in the behavior of the 45–50 week-old group. On the other hand, in the trace paradigm with a stimulus-free trace interval of 500 ms, significant deficits became apparent at the age of 45–50 weeks. These results indicate that trace eyeblink conditioning is more susceptible to age-related deterioration of memory in mice than delay eyeblink conditioning. © 2001 Lippincott Williams & Wilkins, Inc.