Brain ImagingBehavioural and functional anatomical correlates of deception in humansSpence, Sean A.CA; Farrow, Tom F. D.; Herford, Amy E.; Wilkinson, Iain D.1; Zheng, Ying; Woodruff, Peter W. R. Author Information SCANLab, Academic Department of Psychiatry and 1Section of Academic Radiology, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK CACorresponding Author Received 6 June 2001; accepted 9 July 2001 Neuroreport: September 17, 2001 - Volume 12 - Issue 13 - p 2849-2853 Buy Abstract Brain activity in humans telling lies has yet to be elucidated. We developed an objective approach to its investigation, utilizing a computer-based interrogation and fMRI. Interrogatory questions probed recent episodic memory in 30 volunteers studied outside and 10 volunteers studied inside the MR scanner. In a counter-balanced design subjects answered specified questions both truthfully and with lies. Lying was associated with longer response times (p < 0.001) and greater activity in bilateral ventrolateral prefrontal cortices (p < 0.05, corrected). These findings were replicated using an alternative protocol. Ventrolateral prefrontal cortex may be engaged in generating lies or withholding the truth. © 2001 Lippincott Williams & Wilkins, Inc.