Regeneration And TransplantationGroup I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injuryAguirre, José A.CA; Andbjer, Beth1; González-Barón, Salvador; Hansson, Anita1; Strömberg, Ingrid1; Agnati, Luigi F.2; Fuxe, Kjell1Author Information Department of Physiology, School of Medicine, E-29080, Málaga, Spain; 1Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, S-171 77, Stockholm, Sweden; 2Department of Biomedical Sciences, University of Modena, 41100 Modena, Italy CACorresponding Author Received 2 May 2001; accepted 11 June 2001 Neuroreport: August 28th, 2001 - Volume 12 - Issue 12 - p 2615-2617 Buy SDC Abstract The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5%. A 15 min AIDA pre-treatment (10 nmol) selectively counteracted the loss of TH-IR cells caused by MPTP as evaluated 10 days after the insult without changing the total number of non-neuronal cell nuclei. The results suggest that group I mGluR antagonists may have a neuroprotective role against MPTP-induced degeneration of DA neurons and thus probably also against neurodegenerative processes occurring in Parkinson's disease. © 2001 Lippincott Williams & Wilkins, Inc.