Brain ImagingDisordered visual processing and oscillatory brain activity in autism and Williams SyndromeGrice, Sarah J.; Spratling, Michael W.2; Karmiloff-Smith, Annette; Halit, Hanife2; Csibra, Gergely2; de Haan, Michelle1; Johnson, Mark H.2, CA Author Information Neurocognitive Development Unit and 1Developmental Cognitive Neuroscience Unit, Institute of Child Health, London WC1N 1EH; 2Centre for Brain and Cognitive Development, School of Psychology, Birkbeck College, University of London, WC1E 7HX, UK CACorresponding Author Received 6 June 2001; accepted 27 June 2001 Neuroreport: August 28, 2001 - Volume 12 - Issue 12 - p 2697-2700 Buy Abstract Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) γ-band bursts (around 40 Hz) when the brain is required to achieve such binding. Here we explore γ-band EEG in autism and Williams Syndrome and demonstrate differential abnormalities in the two phenotypes. We show that despite putative processing similarities at the cognitive level, binding in Williams syndrome and autism can be dissociated at the neurophysiological level by different abnormalities in underlying brain oscillatory activity. Our study is the first to identify that binding-related γ EEG can be disordered in humans. © 2001 Lippincott Williams & Wilkins, Inc.