Clinical Neuroscience And NeuropathologyCajal-Retzius cell density as marker of type of focal cortical dysplasiaGarbelli, Rita; Frassoni, C.; Ferrario, A.; Tassi, L.1; Bramerio, M.2; Spreafico, R.CAAuthor Information Department of Experimental Neurophysiology, Istituto Nazionale Neurologico C. Besta, Via Celoria 11, 20133 Milano; Departments of 1Epileptic Surgery and 2Pathology, Niguarda Hospital, Milano, Italy CACorresponding Author Received 6 June 2001; accepted 27 June 2001 Neuroreport: August 28th, 2001 - Volume 12 - Issue 12 - p 2767-2771 Buy SDC Abstract Cajal-Retzius cells, identified using calretinin antiserum, were studied in layer I (LI) of adult human temporal cortex from epileptic patients with Taylor's focal cortical dysplasia and architectural dysplasia, in comparison with normal cortex. Both types of dysplasia showed LI hypercellularity, but only in architectural dysplasia was the density of Cajal-Retzius cells significantly increased. A subset of Cajal-Retzius cells were reelin immunoreactive, but none were GABA positive. These findings suggest that differences in the persistence of Cajal-Retzius cells, which probably reflect different types of alteration during brain development, can assist in characterizing different forms of cortical dysplasia. © 2001 Lippincott Williams & Wilkins, Inc.